William Douglas, 4th Duke of Hamilton (1658-1712)

James Douglas, 4th duke of Hamilton (1658-1712), eldest son of the preceding and of Duchess Anne, succeeded his mother, who resigned the dukedom to him in 1698, and at the accession of Queen Anne he was regarded as leader of the Scottish national party. He was an opponent of the union with England, but his lack of decision rendered his political conduct ineffective. He was created duke of Brandon in the peerage of Great Britain in 1711; and on the 15th of November in the following year he fought the celebrated duel with Charles Lord Mohun, narrated in Thackeray's Esmond, in which both the principals were killed. His son, James (1703-1743), became 5th duke, and his grandson James, 6th duke of Hamilton and Brandon (1724-1758), married the famous beauty, Elizabeth Gunning, afterwards duchess of Argyll. James George, 7th duke (1755-1769), became head of the house of Douglas on the death in 1761 of Archibald, ; duke of Douglas, whose titles but not his estates then devolved on the duke of Hamilton as heir-male. Archibald's brother Douglas (1756-1799) was the 8th duke, and when he died childless the titles passed to his uncle Archibald (1740-1810). His son Alexander, 10th duke (1767-1852), who as marquess of Douglas was a great collector and connoisseur of books and pictures (his collections realized £397,562 in 1882), was ambassador at St. Petersburg in 1806-1807. His sister, Lady Anne Hamilton, was lady-in-waiting and a faithful friend to Queen Caroline, wife of George IV.; she did not write the Secret History of the Court of England . . . (1832) to which her name was attached. 

Source: http://www.hamiltongensociety.org/history.htm