Family: Claude (Duke of Guise) De Lorraine / Antoinette (Duchess of Guise) De Bourbon (F39947)
m. 9 Jun 1513
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 | René II (Duke of Bar) Duke of Lorraine (1451-1508)
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 | Philippine De Guelders (1467-1547)
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| Anthony 'Il Buono'(Duke of Lorraine) De Lorraine (1489-1544)  |
| Francois (Comte De Vendome) De Bourbon (1470-1495)
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| Marie De Luxembourg ( -1546)
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| Charles (Duke De Vendôme) De Bourbon (1489-1537) |
| Francois (Duc De St Pol): De Vendôme (1491- ) |
| Antoinette (Duchess of Guise) De Bourbon (1493-1583)
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| Claude (Duke of Guise) De Lorraine (1496-1550)
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| Mary De Guise De Lorraine (1515-1560) |
| Francis De Lorraine (1519- ) |
| Charles (Cardinal) De Lorraine (1524- ) |
| Claude (Duke of D'aumale) D'aumale (1526- ) |
| Louis (Cardinal) Guise ( -1578) |
| Renato (Marchesse D'elbeuf) D'elbeuf (1536- ) |